Drug interactions
Levetiracetam + Zonisamide
Severity: Minor
Levetiracetam and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and fatigue, so adverse CNS effects may be additive. Levetiracetam may also cause irritability and mood changes that can overlap with zonisamide effects.
What this interaction means in plain words
Levetiracetam and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Titrate slowly and monitor for sedation and behavioral changes. Advise caution when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Zonisamide?
MediHelp rates the interaction as minor. Levetiracetam and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence, dizziness and fatigue, so adverse CNS effects may be additive. Levetiracetam may also cause irritability and mood changes that can overlap with zonisamide effects.
How serious is the interaction between Levetiracetam and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate slowly and monitor for sedation and behavioral changes. Advise caution when driving.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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