Drug interactions
Levocetirizine + Pregabalin
Severity: Moderate
Levocetirizine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause somnolence and dizziness. Combined use may increase sedation and psychomotor impairment, with respiratory depression a concern in susceptible patients.
What this interaction means in plain words
Levocetirizine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levocetirizine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective doses and counsel on sedation and driving. Monitor for excessive sedation, particularly in older adults or with renal or respiratory impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Other interactions of Pregabalin
Frequently asked questions
Can I take Levocetirizine with Pregabalin?
MediHelp rates the interaction as moderate. Levocetirizine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause somnolence and dizziness. Combined use may increase sedation and psychomotor impairment, with respiratory depression a concern in susceptible patients.
How serious is the interaction between Levocetirizine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on sedation and driving. Monitor for excessive sedation, particularly in older adults or with renal or respiratory impairment.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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