Drug interactions
Levofloxacin + Levoketoconazole
Severity: Major
Levofloxacin and Levoketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole prolongs the QT interval in a dose-related way and is contraindicated with other QT-prolonging drugs that are CYP3A4 substrates. Levofloxacin also prolongs the QT interval, so combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Levofloxacin and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levofloxacin belongs to Anti Bacterial; Levoketoconazole belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization through potassium channel blockade.
What to do
Avoid the combination and choose an antibiotic without QT effects. If it cannot be avoided, obtain ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levofloxacin with Levoketoconazole?
MediHelp rates the interaction as major. Levofloxacin and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole prolongs the QT interval in a dose-related way and is contraindicated with other QT-prolonging drugs that are CYP3A4 substrates. Levofloxacin also prolongs the QT interval, so combined use raises the risk of torsades de pointes.
How serious is the interaction between Levofloxacin and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic without QT effects. If it cannot be avoided, obtain ECG monitoring and correct electrolytes.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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