Drug interactions
Levofloxacin + Miglitol
Severity: Minor
Levofloxacin and Miglitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause unpredictable hypoglycemia or hyperglycemia in diabetic patients. Miglitol alone seldom causes hypoglycemia, so the effect is mainly a disturbance of overall glucose control.
What this interaction means in plain words
Levofloxacin and Miglitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levofloxacin belongs to Anti Bacterial; Miglitol belongs to Endocrine.
Why it happens
Fluoroquinolone effects on insulin secretion may alter glucose control; this is largely a theoretical pharmacodynamic overlap with miglitol.
What to do
Monitor blood glucose during levofloxacin therapy. Note that hypoglycemia on combined sulfonylurea or insulin therapy should be treated with glucose, not sucrose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Levofloxacin with Miglitol?
MediHelp rates the interaction as minor. Levofloxacin and Miglitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoroquinolones can cause unpredictable hypoglycemia or hyperglycemia in diabetic patients. Miglitol alone seldom causes hypoglycemia, so the effect is mainly a disturbance of overall glucose control.
How serious is the interaction between Levofloxacin and Miglitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during levofloxacin therapy. Note that hypoglycemia on combined sulfonylurea or insulin therapy should be treated with glucose, not sucrose.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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