Drug interactions
Levofloxacin + Mirtazapine
Severity: Moderate
Levofloxacin and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may add to the risk of torsades de pointes. The risk is higher with electrolyte abnormalities, overdose or existing cardiac disease.
What this interaction means in plain words
Levofloxacin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization through potassium channel effects.
What to do
Correct hypokalemia and hypomagnesemia and consider a baseline ECG in patients with risk factors. Monitor the QTc and for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Levofloxacin with Mirtazapine?
MediHelp rates the interaction as moderate. Levofloxacin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may add to the risk of torsades de pointes. The risk is higher with electrolyte abnormalities, overdose or existing cardiac disease.
How serious is the interaction between Levofloxacin and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia and consider a baseline ECG in patients with risk factors. Monitor the QTc and for palpitations or syncope.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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