Drug interactions
Levofloxacin + Mometasone
Severity: Minor
Levofloxacin and Mometasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause tendinopathy and tendon rupture, and corticosteroids add to this risk. With inhaled mometasone the systemic exposure is low, so the added risk is likely small.
What this interaction means in plain words
Levofloxacin and Mometasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levofloxacin belongs to Anti Bacterial; Mometasone belongs to Respiratory.
Why it happens
Additive tendon toxicity of fluoroquinolones and corticosteroids; reduced with low inhaled systemic exposure.
What to do
Advise patients to stop the quinolone and seek review if tendon pain or swelling develops. Take extra care in older patients or those on additional systemic steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Mometasone?
MediHelp rates the interaction as minor. Levofloxacin and Mometasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoroquinolones can cause tendinopathy and tendon rupture, and corticosteroids add to this risk. With inhaled mometasone the systemic exposure is low, so the added risk is likely small.
How serious is the interaction between Levofloxacin and Mometasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to stop the quinolone and seek review if tendon pain or swelling develops. Take extra care in older patients or those on additional systemic steroids.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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