Drug interactions
Levofloxacin + Ranolazine
Severity: Moderate
Levofloxacin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine causes dose-related QT prolongation, and levofloxacin has additive potential. The combination may raise the risk of ventricular arrhythmia, especially with renal or hepatic impairment or electrolyte abnormalities.
What this interaction means in plain words
Levofloxacin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Ranolazine belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolytes, then monitor the QTc during the combination. Consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Levofloxacin with Ranolazine?
MediHelp rates the interaction as moderate. Levofloxacin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine causes dose-related QT prolongation, and levofloxacin has additive potential. The combination may raise the risk of ventricular arrhythmia, especially with renal or hepatic impairment or electrolyte abnormalities.
How serious is the interaction between Levofloxacin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes, then monitor the QTc during the combination. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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