Drug interactions
Levofloxacin + Risperidone
Severity: Moderate
Levofloxacin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbance, bradycardia or structural heart disease.
What this interaction means in plain words
Levofloxacin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Risperidone belongs to Central Nervous System.
Why it happens
Additive delay in ventricular repolarization through hERG potassium channel blockade.
What to do
Check electrolytes and consider a baseline ECG in at-risk patients. Monitor the QTc and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Levofloxacin with Risperidone?
MediHelp rates the interaction as moderate. Levofloxacin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbance, bradycardia or structural heart disease.
How serious is the interaction between Levofloxacin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and consider a baseline ECG in at-risk patients. Monitor the QTc and avoid adding other QT-prolonging drugs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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