Drug interactions
Levofloxacin + Sevoflurane
Severity: Moderate
Levofloxacin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and levofloxacin has a similar effect. Perioperative use of both may increase the risk of torsades de pointes.
What this interaction means in plain words
Levofloxacin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation through delayed ventricular repolarization.
What to do
Inform the anesthesia team and monitor ECG during surgery. Correct potassium and magnesium beforehand in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Levofloxacin with Sevoflurane?
MediHelp rates the interaction as moderate. Levofloxacin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and levofloxacin has a similar effect. Perioperative use of both may increase the risk of torsades de pointes.
How serious is the interaction between Levofloxacin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor ECG during surgery. Correct potassium and magnesium beforehand in patients with other risk factors.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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