Drug interactions
Levofloxacin + Tiotropium-olodaterol
Severity: Moderate
Levofloxacin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval and olodaterol may add to arrhythmic risk through hypokalemia and increased heart rate. The combination is usually manageable but matters in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Levofloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and sympathetic stimulation.
What to do
Check potassium and magnesium and correct abnormalities. Obtain an ECG in patients with long QT, heart failure or other QT-prolonging drugs, or choose an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Levofloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval and olodaterol may add to arrhythmic risk through hypokalemia and increased heart rate. The combination is usually manageable but matters in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Levofloxacin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct abnormalities. Obtain an ECG in patients with long QT, heart failure or other QT-prolonging drugs, or choose an alternative antibiotic.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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