Drug interactions
Levoketoconazole + Memantine-donepezil
Severity: Moderate
Levoketoconazole and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may raise donepezil concentrations. It also prolongs the QT interval, so the combination adds arrhythmia risk and cholinergic adverse effects such as bradycardia.
What this interaction means in plain words
Levoketoconazole and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Memantine-donepezil belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces donepezil clearance, with additive QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc, heart rate and cholinergic effects. Consider lowering the donepezil dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Memantine-donepezil?
MediHelp rates the interaction as moderate. Levoketoconazole and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may raise donepezil concentrations. It also prolongs the QT interval, so the combination adds arrhythmia risk and cholinergic adverse effects such as bradycardia.
How serious is the interaction between Levoketoconazole and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, heart rate and cholinergic effects. Consider lowering the donepezil dose if adverse effects occur.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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