Drug interactions
Levoketoconazole + Mitoxantrone
Severity: Moderate
Levoketoconazole and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits P-glycoprotein and possibly BCRP, both of which transport mitoxantrone. Higher mitoxantrone exposure may increase myelosuppression and cardiac toxicity.
What this interaction means in plain words
Levoketoconazole and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of efflux transporters (P-gp/BCRP) by levoketoconazole may decrease mitoxantrone elimination.
What to do
Monitor complete blood counts and cardiac function more closely. Consider an alternative to levoketoconazole if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levoketoconazole and Mitoxantrone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mitoxantrone
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Mitoxantrone?
MediHelp rates the interaction as moderate. Levoketoconazole and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits P-glycoprotein and possibly BCRP, both of which transport mitoxantrone. Higher mitoxantrone exposure may increase myelosuppression and cardiac toxicity.
How serious is the interaction between Levoketoconazole and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and cardiac function more closely. Consider an alternative to levoketoconazole if toxicity develops.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
