Drug interactions
Levoketoconazole + Nizatidine
Severity: Moderate
Levoketoconazole and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole needs gastric acid for dissolution, so acid suppression can reduce its absorption and its cortisol-lowering effect in Cushing syndrome.
What this interaction means in plain words
Levoketoconazole and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Nizatidine raises gastric pH, reducing dissolution and absorption of levoketoconazole.
What to do
Avoid concurrent use of acid suppressants where possible; if needed, give short-acting antacids at least 2 hours after levoketoconazole and monitor cortisol control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Nizatidine?
MediHelp rates the interaction as moderate. Levoketoconazole and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole needs gastric acid for dissolution, so acid suppression can reduce its absorption and its cortisol-lowering effect in Cushing syndrome.
How serious is the interaction between Levoketoconazole and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of acid suppressants where possible; if needed, give short-acting antacids at least 2 hours after levoketoconazole and monitor cortisol control.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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