Drug interactions
Levoketoconazole + Paclitaxel
Severity: Moderate
Levoketoconazole and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and may increase paclitaxel exposure. This could increase the risk of neutropenia and peripheral neuropathy.
What this interaction means in plain words
Levoketoconazole and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Paclitaxel belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by levoketoconazole reduces paclitaxel clearance.
What to do
Monitor blood counts and neuropathy, and consider reducing the paclitaxel dose or using an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Paclitaxel?
MediHelp rates the interaction as moderate. Levoketoconazole and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and may increase paclitaxel exposure. This could increase the risk of neutropenia and peripheral neuropathy.
How serious is the interaction between Levoketoconazole and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and consider reducing the paclitaxel dose or using an alternative agent.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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