Drug interactions
Levoketoconazole + Prednisone
Severity: Moderate
Levoketoconazole and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may raise exposure to corticosteroids. Prednisone is activated to prednisolone and less dependent on CYP3A4, so the effect is modest, but steroid excess is possible. Levoketoconazole also lowers cortisol synthesis, which may complicate steroid dosing.
What this interaction means in plain words
Levoketoconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4-mediated corticosteroid metabolism and adrenal steroidogenesis.
What to do
Monitor for corticosteroid excess such as hyperglycemia, edema and hypertension, and reduce the prednisone dose if needed. Reassess adrenal status when levoketoconazole is used for Cushing syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Prednisone?
MediHelp rates the interaction as moderate. Levoketoconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may raise exposure to corticosteroids. Prednisone is activated to prednisolone and less dependent on CYP3A4, so the effect is modest, but steroid excess is possible. Levoketoconazole also lowers cortisol synthesis, which may complicate steroid dosing.
How serious is the interaction between Levoketoconazole and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycemia, edema and hypertension, and reduce the prednisone dose if needed. Reassess adrenal status when levoketoconazole is used for Cushing syndrome.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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