Drug interactions
Levoketoconazole + Quinidine
Severity: Contraindicated
Levoketoconazole and Quinidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor that also prolongs the QT interval, and its labeling contraindicates use with QT-prolonging CYP3A substrates. Quinidine concentrations may rise and the combined effect on repolarization can cause torsades de pointes.
What this interaction means in plain words
Levoketoconazole and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Strong CYP3A4 inhibition raises quinidine exposure, with additive QT prolongation.
What to do
Do not co-administer; use an alternative antiarrhythmic or cortisol-lowering therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Quinidine?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor that also prolongs the QT interval, and its labeling contraindicates use with QT-prolonging CYP3A substrates. Quinidine concentrations may rise and the combined effect on repolarization can cause torsades de pointes.
How serious is the interaction between Levoketoconazole and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antiarrhythmic or cortisol-lowering therapy.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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