Drug interactions
Levoketoconazole + Roflumilast
Severity: Moderate
Levoketoconazole and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole strongly inhibits CYP3A4 and can increase exposure to roflumilast and its active metabolite. Greater exposure raises the risk of adverse effects such as diarrhea, weight loss, insomnia, anxiety and depression.
What this interaction means in plain words
Levoketoconazole and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Roflumilast belongs to Respiratory.
Why it happens
Levoketoconazole inhibits CYP3A4, reducing roflumilast clearance.
What to do
Monitor closely for PDE4-related adverse effects and mood or sleep changes. Stop roflumilast if they become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Roflumilast?
MediHelp rates the interaction as moderate. Levoketoconazole and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole strongly inhibits CYP3A4 and can increase exposure to roflumilast and its active metabolite. Greater exposure raises the risk of adverse effects such as diarrhea, weight loss, insomnia, anxiety and depression.
How serious is the interaction between Levoketoconazole and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for PDE4-related adverse effects and mood or sleep changes. Stop roflumilast if they become troublesome.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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