Drug interactions
Levoketoconazole + Saxagliptin-metformin
Severity: Moderate
Levoketoconazole and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and raises saxagliptin and its active metabolite exposure. This may increase saxagliptin-related adverse effects.
What this interaction means in plain words
Levoketoconazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4/5 reduces saxagliptin metabolism to its active metabolite and raises plasma levels of the parent drug.
What to do
Limit saxagliptin to 2.5 mg once daily while levoketoconazole is used, which requires use of the separate-component product rather than the fixed combination if a lower saxagliptin dose is needed. Monitor glycemic control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Levoketoconazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and raises saxagliptin and its active metabolite exposure. This may increase saxagliptin-related adverse effects.
How serious is the interaction between Levoketoconazole and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily while levoketoconazole is used, which requires use of the separate-component product rather than the fixed combination if a lower saxagliptin dose is needed. Monitor glycemic control.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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