Drug interactions
Levoketoconazole + Terbinafine
Severity: Moderate
Levoketoconazole and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP3A4 and CYP2C9 and could raise terbinafine levels somewhat. The effect is probably modest, and combining two antifungal-type agents adds hepatotoxicity concern.
What this interaction means in plain words
Levoketoconazole and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Terbinafine belongs to Anti Fungals.
Why it happens
Levoketoconazole inhibits CYP3A4 and CYP2C9, which contribute to terbinafine metabolism.
What to do
Monitor liver function tests and for terbinafine adverse effects. Avoid combining where possible given the shared hepatotoxicity risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Terbinafine?
MediHelp rates the interaction as moderate. Levoketoconazole and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP3A4 and CYP2C9 and could raise terbinafine levels somewhat. The effect is probably modest, and combining two antifungal-type agents adds hepatotoxicity concern.
How serious is the interaction between Levoketoconazole and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for terbinafine adverse effects. Avoid combining where possible given the shared hepatotoxicity risk.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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