Drug interactions
Levoketoconazole + Tinidazole
Severity: Minor
Levoketoconazole and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, and tinidazole is partly metabolized by CYP3A4, so its exposure may be modestly increased. Clinically, this may raise the chance of tinidazole adverse effects such as nausea or metallic taste.
What this interaction means in plain words
Levoketoconazole and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Tinidazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4-mediated tinidazole metabolism by levoketoconazole.
What to do
No routine dose change is needed for a short tinidazole course; monitor for gastrointestinal and neurologic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Tinidazole?
MediHelp rates the interaction as minor. Levoketoconazole and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a strong CYP3A4 inhibitor, and tinidazole is partly metabolized by CYP3A4, so its exposure may be modestly increased. Clinically, this may raise the chance of tinidazole adverse effects such as nausea or metallic taste.
How serious is the interaction between Levoketoconazole and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for a short tinidazole course; monitor for gastrointestinal and neurologic adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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