Drug interactions
Levoketoconazole + Tolazamide
Severity: Moderate
Levoketoconazole and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azole antifungals can raise sulfonylurea concentrations and cause hypoglycemia. Levoketoconazole is also a strong CYP3A4 inhibitor and may lower glucose in patients with Cushing syndrome, adding to the risk.
What this interaction means in plain words
Levoketoconazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Inhibition of hepatic CYP-mediated metabolism of the sulfonylurea, plus additive glucose lowering from reduced cortisol.
What to do
Monitor blood glucose closely when starting levoketoconazole and reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Tolazamide?
MediHelp rates the interaction as moderate. Levoketoconazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azole antifungals can raise sulfonylurea concentrations and cause hypoglycemia. Levoketoconazole is also a strong CYP3A4 inhibitor and may lower glucose in patients with Cushing syndrome, adding to the risk.
How serious is the interaction between Levoketoconazole and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting levoketoconazole and reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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