Drug interactions
Levoketoconazole + Umeclidinium-vilanterol
Severity: Major
Levoketoconazole and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can raise vilanterol exposure; ketoconazole has been shown to increase vilanterol levels. It also prolongs QT, so cardiovascular risk may be additive.
What this interaction means in plain words
Levoketoconazole and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levoketoconazole belongs to Endocrine; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Levoketoconazole inhibits CYP3A4, reducing vilanterol metabolism, with additive QT-prolonging potential.
What to do
Avoid if possible; otherwise monitor ECG, potassium and heart rate closely and consider an alternative bronchodilator.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Levoketoconazole and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and can raise vilanterol exposure; ketoconazole has been shown to increase vilanterol levels. It also prolongs QT, so cardiovascular risk may be additive.
How serious is the interaction between Levoketoconazole and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG, potassium and heart rate closely and consider an alternative bronchodilator.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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