Drug interactions
Levoketoconazole + Vardenafil
Severity: Major
Levoketoconazole and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and also prolongs the QT interval. Combined with vardenafil it can greatly increase vardenafil exposure, raising the risk of severe hypotension and QT-related arrhythmia.
What this interaction means in plain words
Levoketoconazole and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levoketoconazole belongs to Endocrine; Vardenafil belongs to Genitourinary.
Why it happens
Strong CYP3A4 inhibition reduces vardenafil clearance, with additive QT prolongation.
What to do
If used, limit vardenafil to 2.5 mg in 24 hours and monitor blood pressure and ECG. Prefer an alternative treatment where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Vardenafil?
MediHelp rates the interaction as major. Levoketoconazole and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and also prolongs the QT interval. Combined with vardenafil it can greatly increase vardenafil exposure, raising the risk of severe hypotension and QT-related arrhythmia.
How serious is the interaction between Levoketoconazole and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used, limit vardenafil to 2.5 mg in 24 hours and monitor blood pressure and ECG. Prefer an alternative treatment where possible.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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