Drug interactions
Levomilnacipran + Lurasidone
Severity: Moderate
Levomilnacipran and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an antipsychotic with a serotonin-norepinephrine reuptake inhibitor carries a small risk of serotonin syndrome or neuroleptic malignant syndrome. Lurasidone has 5-HT1A partial agonist activity, which may contribute. The combination is common in practice and is generally tolerated.
What this interaction means in plain words
Levomilnacipran and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects; levomilnacipran increases synaptic serotonin while lurasidone modulates serotonin and dopamine receptors.
What to do
Monitor for agitation, tremor, hyperthermia, autonomic instability, clonus or rigidity, especially at initiation or after dose increases. Stop the drugs and treat if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Lurasidone?
MediHelp rates the interaction as moderate. Levomilnacipran and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an antipsychotic with a serotonin-norepinephrine reuptake inhibitor carries a small risk of serotonin syndrome or neuroleptic malignant syndrome. Lurasidone has 5-HT1A partial agonist activity, which may contribute. The combination is common in practice and is generally tolerated.
How serious is the interaction between Levomilnacipran and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, autonomic instability, clonus or rigidity, especially at initiation or after dose increases. Stop the drugs and treat if serotonin syndrome or NMS is suspected.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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