Drug interactions
Levomilnacipran + Nabumetone
Severity: Moderate
Levomilnacipran and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs such as levomilnacipran reduce platelet serotonin uptake and impair platelet aggregation. Combined with an NSAID, the risk of bleeding, particularly upper gastrointestinal bleeding, is increased.
What this interaction means in plain words
Levomilnacipran and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and NSAID cyclooxygenase inhibition, plus NSAID mucosal injury.
What to do
Counsel patients to report gastrointestinal bleeding or easy bruising and consider a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Nabumetone?
MediHelp rates the interaction as moderate. Levomilnacipran and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs such as levomilnacipran reduce platelet serotonin uptake and impair platelet aggregation. Combined with an NSAID, the risk of bleeding, particularly upper gastrointestinal bleeding, is increased.
How serious is the interaction between Levomilnacipran and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report gastrointestinal bleeding or easy bruising and consider a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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