Drug interactions
Levomilnacipran + Pentazocine
Severity: Moderate
Levomilnacipran and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor and pentazocine has been linked to serotonergic effects. The combination may raise the risk of serotonin syndrome, though the evidence for pentazocine is limited. Seizure threshold may also be lowered.
What this interaction means in plain words
Levomilnacipran and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic activity; pentazocine's serotonergic contribution is not well established.
What to do
Monitor for agitation, tremor, hyperreflexia, sweating and fever, especially at initiation or dose increases. Stop one or both drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Pentazocine?
MediHelp rates the interaction as moderate. Levomilnacipran and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor and pentazocine has been linked to serotonergic effects. The combination may raise the risk of serotonin syndrome, though the evidence for pentazocine is limited. Seizure threshold may also be lowered.
How serious is the interaction between Levomilnacipran and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, sweating and fever, especially at initiation or dose increases. Stop one or both drugs if serotonin syndrome is suspected.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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