Drug interactions
Levomilnacipran + Torsemide
Severity: Moderate
Levomilnacipran and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics and serotonin-norepinephrine reuptake inhibitors can each cause hyponatremia, particularly in older adults. Using them together may raise the risk of low sodium.
What this interaction means in plain words
Levomilnacipran and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced sodium loss combined with SNRI-associated inappropriate antidiuretic hormone secretion.
What to do
Check serum sodium at baseline and within the first weeks of therapy, especially in elderly patients. Stop or change therapy if symptomatic hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Torsemide?
MediHelp rates the interaction as moderate. Levomilnacipran and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics and serotonin-norepinephrine reuptake inhibitors can each cause hyponatremia, particularly in older adults. Using them together may raise the risk of low sodium.
How serious is the interaction between Levomilnacipran and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and within the first weeks of therapy, especially in elderly patients. Stop or change therapy if symptomatic hyponatremia develops.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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