Drug interactions
Levomilnacipran + Zolmitriptan
Severity: Moderate
Levomilnacipran and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is an SNRI, and with zolmitriptan it can occasionally cause serotonin syndrome, a risk noted in labeling for both drug classes.
What this interaction means in plain words
Levomilnacipran and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition and 5-HT1B/1D agonism.
What to do
Monitor for serotonin syndrome, especially at initiation or dose increases, and tell patients which symptoms to report. Stop the serotonergic drugs if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Zolmitriptan?
MediHelp rates the interaction as moderate. Levomilnacipran and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is an SNRI, and with zolmitriptan it can occasionally cause serotonin syndrome, a risk noted in labeling for both drug classes.
How serious is the interaction between Levomilnacipran and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, especially at initiation or dose increases, and tell patients which symptoms to report. Stop the serotonergic drugs if it develops.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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