Drug interactions
Levonorgestrel + Maraviroc
Severity: Minor
Levonorgestrel and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levonorgestrel is not a meaningful CYP3A4 inhibitor, and no clinically relevant rise in maraviroc exposure is expected. Studies of maraviroc with combined oral contraceptives showed no meaningful effect on either drug.
What this interaction means in plain words
Levonorgestrel and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Maraviroc belongs to Anti Virals.
Why it happens
No established mechanism; a pharmacokinetic interaction is not expected at contraceptive doses.
What to do
No dose adjustment of maraviroc or levonorgestrel is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Levonorgestrel with Maraviroc?
MediHelp rates the interaction as minor. Levonorgestrel and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levonorgestrel is not a meaningful CYP3A4 inhibitor, and no clinically relevant rise in maraviroc exposure is expected. Studies of maraviroc with combined oral contraceptives showed no meaningful effect on either drug.
How serious is the interaction between Levonorgestrel and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of maraviroc or levonorgestrel is required.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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