Drug interactions
Levonorgestrel + Perampanel
Severity: Moderate
Levonorgestrel and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses perampanel lowers levonorgestrel exposure, which may reduce the effectiveness of oral contraceptives. The effect on intrauterine delivery is expected to be small.
What this interaction means in plain words
Levonorgestrel and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Perampanel belongs to Central Nervous System.
Why it happens
Perampanel likely induces enzymes involved in levonorgestrel metabolism, though the mechanism is not fully established.
What to do
For patients on perampanel 12 mg daily, add a barrier method or use an IUD or other nonhormonal option. Reassess contraceptive reliability when perampanel dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Levonorgestrel with Perampanel?
MediHelp rates the interaction as moderate. Levonorgestrel and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses perampanel lowers levonorgestrel exposure, which may reduce the effectiveness of oral contraceptives. The effect on intrauterine delivery is expected to be small.
How serious is the interaction between Levonorgestrel and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For patients on perampanel 12 mg daily, add a barrier method or use an IUD or other nonhormonal option. Reassess contraceptive reliability when perampanel dose changes.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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