Drug interactions
Levonorgestrel + Teriflunomide
Severity: Minor
Levonorgestrel and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide has been shown to raise exposure to ethinylestradiol and levonorgestrel in oral contraceptive studies. Hormonal adverse effects may increase, though contraceptive efficacy is not reduced.
What this interaction means in plain words
Levonorgestrel and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Mechanism is not established; possible inhibition of transporters such as BCRP or effects on metabolism.
What to do
No dose change needed; select the contraceptive with attention to estrogen-related adverse effects and counsel on teriflunomide pregnancy precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Teriflunomide?
MediHelp rates the interaction as minor. Levonorgestrel and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide has been shown to raise exposure to ethinylestradiol and levonorgestrel in oral contraceptive studies. Hormonal adverse effects may increase, though contraceptive efficacy is not reduced.
How serious is the interaction between Levonorgestrel and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; select the contraceptive with attention to estrogen-related adverse effects and counsel on teriflunomide pregnancy precautions.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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