Drug interactions
Levonorgestrel + Tucatinib
Severity: Minor
Levonorgestrel and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may increase levonorgestrel exposure, potentially intensifying progestogenic adverse effects. Serious toxicity is unlikely given levonorgestrel's wide margin.
What this interaction means in plain words
Levonorgestrel and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
CYP3A inhibition reduces levonorgestrel clearance.
What to do
No dose change is routinely needed; monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Levonorgestrel with Tucatinib?
MediHelp rates the interaction as minor. Levonorgestrel and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib is a strong CYP3A inhibitor and may increase levonorgestrel exposure, potentially intensifying progestogenic adverse effects. Serious toxicity is unlikely given levonorgestrel's wide margin.
How serious is the interaction between Levonorgestrel and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for progestogenic adverse effects.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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