Drug interactions
Levothyroxine + Pretomanid
Severity: Minor
Levothyroxine and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3 in vitro, and this transporter may contribute to thyroid hormone uptake. A clinically meaningful effect on levothyroxine exposure has not been established.
What this interaction means in plain words
Levothyroxine and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levothyroxine belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of OATP1B3-mediated transport; the clinical relevance for levothyroxine is not established.
What to do
No routine dose change is needed. Check TSH if symptoms of thyroid imbalance appear during pretomanid treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levothyroxine and Pretomanid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levothyroxine
Other interactions of Pretomanid
Frequently asked questions
Can I take Levothyroxine with Pretomanid?
MediHelp rates the interaction as minor. Levothyroxine and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OATP1B3 in vitro, and this transporter may contribute to thyroid hormone uptake. A clinically meaningful effect on levothyroxine exposure has not been established.
How serious is the interaction between Levothyroxine and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check TSH if symptoms of thyroid imbalance appear during pretomanid treatment.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
