Drug interactions
Levothyroxine + Trimipramine
Severity: Moderate
Levothyroxine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can increase the sensitivity of adrenergic receptors and may enhance the cardiac and CNS effects of tricyclic antidepressants. This can result in tachycardia, arrhythmias and agitation, although thyroid hormone is also sometimes used deliberately to augment antidepressants.
What this interaction means in plain words
Levothyroxine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Increased adrenergic receptor sensitivity, leading to enhanced tricyclic cardiovascular and CNS effects.
What to do
Monitor heart rate, rhythm and mental status when starting or increasing either drug. Keep the levothyroxine dose at the lowest level that normalizes thyroid function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Levothyroxine
Frequently asked questions
Can I take Levothyroxine with Trimipramine?
MediHelp rates the interaction as moderate. Levothyroxine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can increase the sensitivity of adrenergic receptors and may enhance the cardiac and CNS effects of tricyclic antidepressants. This can result in tachycardia, arrhythmias and agitation, although thyroid hormone is also sometimes used deliberately to augment antidepressants.
How serious is the interaction between Levothyroxine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental status when starting or increasing either drug. Keep the levothyroxine dose at the lowest level that normalizes thyroid function.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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