Drug interactions
Lidocaine-prilocaine + Rucaparib
Severity: Minor
Lidocaine-prilocaine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2 and could raise lidocaine concentrations. With topical lidocaine-prilocaine, systemic exposure is low and a clinically significant effect is unlikely.
What this interaction means in plain words
Lidocaine-prilocaine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2, reducing lidocaine clearance.
What to do
No action is needed for routine topical use. Monitor for lidocaine toxicity if large areas are treated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Rucaparib?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2 and could raise lidocaine concentrations. With topical lidocaine-prilocaine, systemic exposure is low and a clinically significant effect is unlikely.
How serious is the interaction between Lidocaine-prilocaine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for routine topical use. Monitor for lidocaine toxicity if large areas are treated.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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