Drug interactions
Lidocaine-prilocaine + Stiripentol
Severity: Minor
Lidocaine-prilocaine and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce CYP enzymes including CYP1A2, which may change lidocaine exposure. With topical lidocaine-prilocaine the systemic effect is small and a clinically significant change is unlikely.
What this interaction means in plain words
Lidocaine-prilocaine and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP1A2 activity, altering lidocaine metabolism.
What to do
No routine adjustment is needed for limited topical use. Avoid extensive application and watch for toxicity or reduced anesthetic effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Lidocaine-prilocaine with Stiripentol?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol can inhibit and induce CYP enzymes including CYP1A2, which may change lidocaine exposure. With topical lidocaine-prilocaine the systemic effect is small and a clinically significant change is unlikely.
How serious is the interaction between Lidocaine-prilocaine and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for limited topical use. Avoid extensive application and watch for toxicity or reduced anesthetic effect.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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