Drug interactions
Linagliptin + Mitotane
Severity: Moderate
Linagliptin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer with effects persisting for weeks after stopping, and it may substantially lower linagliptin exposure. This could lead to loss of glycemic control.
What this interaction means in plain words
Linagliptin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Mitotane belongs to Oncology.
Why it happens
Strong induction of CYP3A4 (and likely P-gp) increases linagliptin clearance.
What to do
Monitor glucose and HbA1c, and use an antidiabetic agent not affected by induction if control is lost; remember the inducing effect persists after mitotane is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Linagliptin with Mitotane?
MediHelp rates the interaction as moderate. Linagliptin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer with effects persisting for weeks after stopping, and it may substantially lower linagliptin exposure. This could lead to loss of glycemic control.
How serious is the interaction between Linagliptin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c, and use an antidiabetic agent not affected by induction if control is lost; remember the inducing effect persists after mitotane is stopped.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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