Drug interactions
Linagliptin + Prednisone
Severity: Moderate
Linagliptin and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is not a clinically significant CYP3A4 inducer, so no meaningful pharmacokinetic effect on linagliptin is expected. However, corticosteroids raise blood glucose and can oppose the glucose-lowering effect of linagliptin.
What this interaction means in plain words
Linagliptin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as glucocorticoids increase hepatic glucose output and insulin resistance.
What to do
Monitor blood glucose closely during prednisone therapy and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Linagliptin with Prednisone?
MediHelp rates the interaction as moderate. Linagliptin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone is not a clinically significant CYP3A4 inducer, so no meaningful pharmacokinetic effect on linagliptin is expected. However, corticosteroids raise blood glucose and can oppose the glucose-lowering effect of linagliptin.
How serious is the interaction between Linagliptin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during prednisone therapy and adjust antidiabetic therapy as needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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