Drug interactions
Linagliptin + Rifapentine
Severity: Moderate
Linagliptin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP3A4 and likely P-glycoprotein, so it is expected to reduce linagliptin concentrations similarly to rifampin. This may reduce glucose-lowering efficacy.
What this interaction means in plain words
Linagliptin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 and P-glycoprotein, increasing linagliptin clearance.
What to do
Monitor blood glucose during and after rifapentine therapy. Use an alternative antidiabetic agent if glycemic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Linagliptin with Rifapentine?
MediHelp rates the interaction as moderate. Linagliptin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an inducer of CYP3A4 and likely P-glycoprotein, so it is expected to reduce linagliptin concentrations similarly to rifampin. This may reduce glucose-lowering efficacy.
How serious is the interaction between Linagliptin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after rifapentine therapy. Use an alternative antidiabetic agent if glycemic control worsens.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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