Drug interactions
Linagliptin + Sarecycline
Severity: Minor
Linagliptin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline has been reported to inhibit P-glycoprotein in vitro, which could raise linagliptin levels. Systemic exposure from sarecycline is modest and linagliptin has a wide therapeutic margin, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Linagliptin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline reducing linagliptin efflux.
What to do
No routine adjustment is needed. Monitor blood glucose if the patient is unwell or if glycemic changes occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Linagliptin with Sarecycline?
MediHelp rates the interaction as minor. Linagliptin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline has been reported to inhibit P-glycoprotein in vitro, which could raise linagliptin levels. Systemic exposure from sarecycline is modest and linagliptin has a wide therapeutic margin, so a clinically meaningful effect is unlikely.
How serious is the interaction between Linagliptin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood glucose if the patient is unwell or if glycemic changes occur.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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