Drug interactions
Linagliptin + Tolbutamide
Severity: Moderate
Linagliptin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin has low intrinsic hypoglycemic risk but increases hypoglycemia risk when added to a sulfonylurea such as tolbutamide.
What this interaction means in plain words
Linagliptin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects via DPP-4 inhibition raising incretin-mediated insulin secretion plus sulfonylurea-driven insulin release.
What to do
Consider a lower tolbutamide dose when adding linagliptin and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Linagliptin with Tolbutamide?
MediHelp rates the interaction as moderate. Linagliptin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin has low intrinsic hypoglycemic risk but increases hypoglycemia risk when added to a sulfonylurea such as tolbutamide.
How serious is the interaction between Linagliptin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower tolbutamide dose when adding linagliptin and monitor blood glucose.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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