Drug interactions
Linagliptin-metformin + Nevirapine
Severity: Moderate
Linagliptin-metformin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is a CYP3A4 inducer and may lower linagliptin exposure, potentially reducing its glucose-lowering effect. Linagliptin is also a P-gp substrate, and the effect of induction is expected to be modest but may matter for glycemic control.
What this interaction means in plain words
Linagliptin-metformin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases linagliptin clearance.
What to do
Monitor glucose and HbA1c after starting nevirapine and consider an alternative or additional antidiabetic agent if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Linagliptin-metformin with Nevirapine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is a CYP3A4 inducer and may lower linagliptin exposure, potentially reducing its glucose-lowering effect. Linagliptin is also a P-gp substrate, and the effect of induction is expected to be modest but may matter for glycemic control.
How serious is the interaction between Linagliptin-metformin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting nevirapine and consider an alternative or additional antidiabetic agent if control deteriorates.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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