Drug interactions
Linagliptin-metformin + Ondansetron
Severity: Minor
Linagliptin-metformin and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron may inhibit renal organic cation transporters involved in metformin secretion, potentially modestly increasing metformin concentrations. The clinical significance is generally small in patients with normal renal function.
What this interaction means in plain words
Linagliptin-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of OCT/MATE transporters may reduce renal tubular secretion of metformin.
What to do
No routine change is needed; be alert to metformin adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linagliptin-metformin and Ondansetron, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin-metformin
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Linagliptin-metformin with Ondansetron?
MediHelp rates the interaction as minor. Linagliptin-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron may inhibit renal organic cation transporters involved in metformin secretion, potentially modestly increasing metformin concentrations. The clinical significance is generally small in patients with normal renal function.
How serious is the interaction between Linagliptin-metformin and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; be alert to metformin adverse effects in patients with renal impairment.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
