Drug interactions
Linagliptin-metformin + Temsirolimus
Severity: Moderate
Linagliptin-metformin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus commonly causes hyperglycemia and may reduce the effectiveness of antidiabetic therapy. Glucose control may need to be tightened during treatment.
What this interaction means in plain words
Linagliptin-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
Pharmacodynamic antagonism, as mTOR inhibition causes insulin resistance and impaired insulin signaling.
What to do
Monitor blood glucose frequently during temsirolimus therapy and adjust antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Temsirolimus?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus commonly causes hyperglycemia and may reduce the effectiveness of antidiabetic therapy. Glucose control may need to be tightened during treatment.
How serious is the interaction between Linagliptin-metformin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during temsirolimus therapy and adjust antidiabetic treatment as needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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