Drug interactions
Linezolid + Mirtazapine
Severity: Major
Linezolid and Mirtazapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine enhances serotonin and noradrenaline transmission, so with linezolid it may contribute to serotonin syndrome. The risk is considered lower than with SSRIs but still relevant.
What this interaction means in plain words
Linezolid and Mirtazapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from linezolid MAO inhibition and mirtazapine receptor-mediated enhancement of monoaminergic release.
What to do
Prefer another antibiotic. If linezolid is necessary, consider holding mirtazapine and monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Linezolid with Mirtazapine?
MediHelp rates the interaction as major. Linezolid and Mirtazapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mirtazapine enhances serotonin and noradrenaline transmission, so with linezolid it may contribute to serotonin syndrome. The risk is considered lower than with SSRIs but still relevant.
How serious is the interaction between Linezolid and Mirtazapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer another antibiotic. If linezolid is necessary, consider holding mirtazapine and monitor for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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