Drug interactions
Linezolid + Modafinil
Severity: Moderate
Linezolid and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil has weak sympathomimetic activity, and linezolid's MAO inhibition may enhance pressor responses. A rise in blood pressure is possible but the interaction is less well documented than with amphetamines.
What this interaction means in plain words
Linezolid and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Modafinil belongs to Central Nervous System.
Why it happens
Possible additive sympathomimetic effects with MAO inhibition by linezolid.
What to do
Monitor blood pressure and heart rate during combined use, and consider holding modafinil during a short linezolid course if readings rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Linezolid with Modafinil?
MediHelp rates the interaction as moderate. Linezolid and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil has weak sympathomimetic activity, and linezolid's MAO inhibition may enhance pressor responses. A rise in blood pressure is possible but the interaction is less well documented than with amphetamines.
How serious is the interaction between Linezolid and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during combined use, and consider holding modafinil during a short linezolid course if readings rise.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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