Drug interactions
Linezolid + Oxycodone
Severity: Major
Linezolid and Oxycodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a reversible nonselective MAO inhibitor and may precipitate serotonin syndrome or enhanced opioid toxicity with oxycodone. Features include agitation, hyperthermia, hypotension and CNS depression.
What this interaction means in plain words
Linezolid and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Oxycodone belongs to Musculoskeletal.
Why it happens
Linezolid MAO inhibition with opioid serotonergic and CNS depressant effects.
What to do
Avoid the combination where possible and use an alternative analgesic or antibiotic. If unavoidable, use the lowest oxycodone dose and monitor closely for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Oxycodone?
MediHelp rates the interaction as major. Linezolid and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid is a reversible nonselective MAO inhibitor and may precipitate serotonin syndrome or enhanced opioid toxicity with oxycodone. Features include agitation, hyperthermia, hypotension and CNS depression.
How serious is the interaction between Linezolid and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative analgesic or antibiotic. If unavoidable, use the lowest oxycodone dose and monitor closely for serotonin toxicity.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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