Drug interactions
Linezolid + Risperidone
Severity: Moderate
Linezolid and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and risperidone blocks 5-HT2A and D2 receptors. Serotonin toxicity or neuroleptic malignant syndrome has been reported rarely with MAO inhibitors and antipsychotics. The overall risk is low but potentially serious.
What this interaction means in plain words
Linezolid and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Risperidone belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic modulation from MAO inhibition and antipsychotic receptor blockade.
What to do
Monitor for mental status change, neuromuscular hyperactivity, hyperthermia and rigidity during linezolid therapy. Stop the drugs and treat supportively if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Linezolid with Risperidone?
MediHelp rates the interaction as moderate. Linezolid and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits MAO and risperidone blocks 5-HT2A and D2 receptors. Serotonin toxicity or neuroleptic malignant syndrome has been reported rarely with MAO inhibitors and antipsychotics. The overall risk is low but potentially serious.
How serious is the interaction between Linezolid and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, neuromuscular hyperactivity, hyperthermia and rigidity during linezolid therapy. Stop the drugs and treat supportively if toxicity is suspected.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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