Drug interactions
Linezolid + Rizatriptan
Severity: Major
Linezolid and Rizatriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan is metabolized mainly by MAO-A, so linezolid can raise its levels, and both agents add to serotonergic activity. This increases the risk of serotonin syndrome and excessive triptan effect.
What this interaction means in plain words
Linezolid and Rizatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Rizatriptan belongs to Central Nervous System.
Why it happens
Inhibition of MAO-A metabolism of rizatriptan plus additive serotonergic effects.
What to do
Avoid rizatriptan during and for 2 weeks after MAOI use as labeled; use an alternative migraine therapy and monitor for serotonin toxicity if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Linezolid with Rizatriptan?
MediHelp rates the interaction as major. Linezolid and Rizatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rizatriptan is metabolized mainly by MAO-A, so linezolid can raise its levels, and both agents add to serotonergic activity. This increases the risk of serotonin syndrome and excessive triptan effect.
How serious is the interaction between Linezolid and Rizatriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rizatriptan during and for 2 weeks after MAOI use as labeled; use an alternative migraine therapy and monitor for serotonin toxicity if exposure occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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