Drug interactions
Linezolid + Sevoflurane
Severity: Minor
Linezolid and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Evidence of a clinically important interaction is limited. As a reversible MAO inhibitor, linezolid may cause some hemodynamic instability under anesthesia, but no specific effect on sevoflurane has been established.
What this interaction means in plain words
Linezolid and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linezolid belongs to Anti Bacterial; Sevoflurane belongs to Central Nervous System.
Why it happens
Mechanism is not established; possible additive hemodynamic effects.
What to do
Inform the anesthesia team about linezolid use and monitor blood pressure and heart rate perioperatively.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Linezolid with Sevoflurane?
MediHelp rates the interaction as minor. Linezolid and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Evidence of a clinically important interaction is limited. As a reversible MAO inhibitor, linezolid may cause some hemodynamic instability under anesthesia, but no specific effect on sevoflurane has been established.
How serious is the interaction between Linezolid and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about linezolid use and monitor blood pressure and heart rate perioperatively.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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